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An enzyme that influences sebum production, a big contributing factor in hormonal mediated acne. Being able to inhibit this enzyme's activity is of great benefit to eliminating acne. Azelaic acid is: - Antibacterial: it reduces the growth of bacteria in the follicle (Propionibacterium acnes and Staphylococcus epidermidis);
- Keratolytic & comedolytic: it returns to normal, the disordered growth of the skin cells, lining the follicle;
- Scavenger of free radicals and reduces inflammation.
- Reduces pigmentation: it is particularly useful for darker-skinned patients, who have melasma, or whose acne spots leave persistent brown marks; (Per the product insert: "There have been reports of hypopigmentation after use of azelaic acid. Since azelaic acid has not been well studied in patients with dark complexions, these patients should be monitored for early signs of hypopigmentation.")
- Non-toxic, and is well tolerated by most patients.
Azelaic acid does not result in: - bacterial resistance to antibiotics
- reduction in sebum production
- photosensitivity (easy sunburn)
- staining of skin or clothing
- bleaching of normal skin or clothing
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